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Dec 12, 2020 degradation modeling of poly-l-lactide acid (plla) bioresorbable vascular scaffold within a coronary artery.
Specifically for medical applications [5][21]-[24], predictable degradation of biodegradable polymer materials is crucial for drug delivery capsules.
Sep 29, 2017 multiscale models of degradation and healing of bone tissue to the design of biodegradable, biocompatible polymer nanocomposite.
Thus, we introduced a damage function scaling a neo-hookean model to describe mechanical properties of the degrading graft; a refinement to existing mass-.
Feb 19, 2021 a validated computational model of the degradation process can facilitate the tuning of implant biodegradation by changing design properties.
Oct 20, 2018 understanding, and ultimately, predicting the degradation of bioresorbable composites made of biodegradable polyesters and calcium-based.
Nov 3, 2014 this study established a numerical model to investigate the degradation mechanism and behavior of bioabsorbable cardiovascular stents.
Biomedical degradable polymer materials are widely used in medicine because of their excellent mechanical properties and degradation properties. The matching of strength change and degradation rate in the degradation process is a crucial consideration in the design of polymer devices.
The use of bioresorbable polymers in stents, fixation devices and tissue engineering is revolutionising medicine. Both industry and academic researchers are interested in using computer modelling to replace some experiments which are costly and time consuming.
The objective of this work is to develop, in a finite element framework, a model of magnesium degradation that is able to predict the corrosion rate, thus providing a valuable tool for the design of bioresorbable stents. Continuum damage mechanics is suitable for modeling several damage mechanisms, including different types of corrosion.
Mechanical properties of biodegradable polymers 171 entanglements may reduce the value of elongation-at-break. Stiffness increases with molecular weight, although as a result of the complexity of molecular interactions and - selection from modelling degradation of bioresorbable polymeric medical devices [book].
Degradation rate of bioresorbable materials provides a comprehensive review of the most important techniques in safely predicting and evaluating the degradation rate of polymer, ceramic and composite based biomaterials. Part one provides an introductory review of bioresorbable materials and the biological environment of the body.
Deposition modelling/fused filament fabrication (fdm/fff) based on established and federal drug administration (fda)-approved polymers. Manufacturability, mechanical characterization, and accelerated degradation studies have been conducted to evaluate the suitability of each material for te/rm applications.
Apr 2, 2019 [13] developed a degradation model and predicted the corrosion effects on the mechanical integrity of bioabsorbable metallic stents.
A general mathematical framework has been developed through several phd projects at leicester to model the degradation of bioresorbable polymers. The first part reviews the existing understanding of bioresorbable polymer degradation. In the second part, the previous models are simplified and improved.
Part one provides an introductory review of bioresorbable materials and the biological environment of the body. Chapters in part two address degradation mechanisms of commonly used materials such as polymers and ceramics. This is followed by chapters on bioresorption test methods and modelling techniques in part three.
Modelling degradation of bioresorbable polymeric medical devices book description the use of bioresorbable polymers in stents, fixation devices and tissue engineering is revolutionising medicine. Both industry and academic researchers are interested in using computer modelling to replace some experiments which are costly and time consuming.
There are still unknown’s regarding the degradation of bioresorbable polymers and consequently there is an opportunity to improve the ability to accurately predict and tailor resorption rates. Anderson et al [32] proposes a kinetic model to relate molecular weight changes to bulk hydrolysis degradation.
Results 6 - 18 constitutive modeling of biodegradable polymers model involving degradation and its impact on mechanical properties was developed through.
A modelling framework which characterises the degradation of bioresorbable composites was generated by generalising a computational model previously reported in literature. The framework uses mathematical expressions to represent the interwoven phenomena present during degradation.
Part two looks at a wide range of degradation theories for bioresorbable polymers and devices. The final set of chapters look at advances in modelling biodegradation of bioresorbable polymers. This book is an essential guide to those concerned with replacing tests and experiments with modelling.
Jul 19, 2019 biodegradable polymers have been used for a variety of biomedical devices since the middle of the 20th century.
Index242 geometric relations, 76–7 ions conservation, 78–9 molecular weight of polymer phase, 82 representative units of composite materials, 76 tcp dissolution rate, 77–8 polymer - selection from modelling degradation of bioresorbable polymeric medical devices [book].
Aug 5, 2019 the performance of biodegradable magnesium alloy stents (bmgs) tive meshing for modeling degradation, improved the stent long-term.
Pan, jingzhe is the author of 'modelling degradation of bioresorbable polymeric medical devices', published 2014 under isbn 9781782420163 and isbn 1782420169.
The entire field would benefit enormously from mathematical models capable of predicting the degradation and property change of the devices. This phd project will develop such models as following: a) a multi-scale model for degradation of bioresorbable polyesters was developed.
Model of the thermal degradation of pdlga from melt processing that can be applied to processes.
Nov 12, 2014 limited work in modeling biodegradable stent coatings for drug delivery. Modeling the plga degradation and erosion is a prereq- uisite for drug.
The model should incorporate the important physicochemical processes responsible for the polymer degradation and drug release. Such a model can be used to study the effect of different coating parameters and configurations on the degradation and the release of the drug from the coating.
Chapters in part one provide readers with an overview of the fundamentals of biodegradation. Part two looks at a wide range of degradation theories for bioresorbable polymers and devices. The final set of chapters look at advances in modelling biodegradation of bioresorbable polymers.
While, bioresorbable polymers will be resorbed in vivo after degradation such that their degradation products are further metabolized or made to disappear via urinary excretion or citric acid cycle (cac). [ 15, 16] thus, the bioresorption process is eventually ended with a total polymer elimination.
There are at least three good reasons to model the degradation of bioresorbable materials. Firstly, it can help in elucidating and understanding the underlying mechanisms of degradation.
This chapter discusses the development of computational degradation models for different bioresorbable composite materials.
Degradation rate of bioresorbable materials by f j buchanan, 9781845693299, available at book depository with free delivery worldwide.
Process-induced degradation of clinically relevant resorbable polymers was investigated for two thermal techniques, filament extrusion followed by fused deposition modelling (fdm). The aim was to develop a clear understanding of the relationship between temperature, processing time and resultant process-induced degradation.
Scale and their coupling) for modeling degradation of bioresorbable polyesters and provides understand- ing to the process of degradation of biodegradable polymers.
This chapter represents a brief introduction to the available approaches aimed at modeling the degradation of bioresorbable polymers.
Dec 5, 2017 often times, this can be misconstrued to be a variety of degradation mechanisms including surface erosion, bulk erosion, among others.
A phenomenological model for the degradation of biodegradable polymers.
A diffusion based, concentration gradient-driven mechanistic model of mass loss through surface erosion was introduced which can be extended to an in vivo setting through the use of two degradation parameters. Furthermore, notably, mechanical properties of degrading grafts did not scale with mass loss.
A multi-scale method for modeling degradation of bioresorbable polyesters. Zhang t zhou s gao x yang z sun l zhang d acta biomater 50:462-475, 23 dec 2016.
Modelling of the degradation processes for bioresorbable polymers.
Finally the polymer degradation model and the young‟s modulus decay model is integrated with a bone remodelling model and stress analysis to predict the growth or decay of a healing bone that is “protected” by a bioresorbable fixation device.
And known degradation modes and products are indicated based on key words: biodegradable polymers, tissue engineering, study of model compounds.
Results 6 - 18 bone tissue engineering scaffolds made of biodegradable material for bone replacement has been shown to be a promising scaffold for triggering.
The development of robust computational modelling techniques which fully capture the degradation behaviour of these bioabsorbable materials is a key factor in the design of bioabsorable stents.
Jan 4, 2014 abstract the rate of hydrolytic degradation of tissue‐engineered scaffolds made from bioresorbable polyesters is dependent on several.
The rate of hydrolytic degradation of tissue‐engineered scaffolds made from bioresorbable polyesters is dependent on several factors. Some are related to the properties of the degrading polymeric material, but others are related to the geometry of the porous structure and the operating environment.
A phenomenological mathematical modelling framework for the degradation of bioresorbable composites pp 215-244 cite as experimental degradation study of plga–caco \(_\mathrm3\) nanocomposites authors.
5 conclusions in this chapter, we introduce molecular and multi-scale modelling methods of polymer device degradation. Molecular models can consider the detailed informa- - selection from modelling degradation of bioresorbable polymeric medical devices [book].
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