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Calcium folinate is contraindicated in patients who have previously shown hypersensitivity to folinate or any of the excipients. Calcium folinate injection is contraindicated in the treatment of pernicious anaemia or other megaloblastic anaemias where vitamin b 12 is deficient. Its use can lead to an apparent response of the haematopoietic system, but neurological damage may occur or progress if already present.
Calcium folinate solution for injection contains the same active ingredient in the same concentration as leucovorin calcium for injection when the latter is reconstituted with water.
It is a naturally occurring compound that has a vital role in various metabolic pathways. Calcium folinate (cf) drug is also used in the treatment of anemia, during pregnancy.
Calcium (2s)-2- [ (4- [ (2-amino-5-formyl -4-oxo-1,4,5,6,7,8- hexahydropteridin-6 -yl)methyl]aminoph enyl)formamido]pent anedioate.
Calcium folinate is the calcium salt of 5-formyl tetrahydrofolic acid. It is an active metabolite of folinic acid and an essential coenzyme for nucleic acid synthesis in cytotoxic therapy. Calcium folinate is frequently used to diminish the toxicity and counteract the action of folate antagonists, such as methotrexate.
Calcium folinate (cf) is a calcium salt of the calcium formyl tetrahydrofolate derivative, being the activated form of folic acid in the body. It is mainly used as the antidotes of the folic acid antagonist.
Chebi leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor ), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs.
Calcium folinate stabilizes the complex between 5-fu and thymidylate synthase and thus augments 5-fu cytotoxicity.
Calcium folinate is mainly used for colorectal cancer treatment in association with 5-fluorouracil and oxaliplatin (folfox egimen) or with 5-fluorouracil and irinotecan (folfiri regimen). Additionally, it is administered as salvage therapy to reduce toxic effects after high doses of methotrexate in the treatment of some neoplastic diseases, rheumatoid arthritis or severe psoriasis.
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